jarlife journal

AND option

OR option

Current issue

Ahead of print articles

Check out a preview articles to be published in the next issue.

 

JARLIFE Vol 11, 2022

 

UTILITY OF POLYGENIC RISK SCORING TO PREDICT COGNITIVE IMPAIRMENT AS MEASURED BY PRECLINICAL ALZHEIMER COGNITIVE COMPOSITE SCORE

Q. Gao, P. Daunt, A.M. Gibson, R.J. Pither, for the Alzheimer’s Disease Neuroimaging Initiative

J Aging Res & Lifestyle 2022;11:1-8

Show summaryHide summary

Background: The utility of Polygenic Risk Scores (PRS) is gaining increasing attention for generating an individual genetic risk profile to predict subsequent likelihood of future onset of Alzheimer’s disease (AD), especially those carry two copies of the APOE E3 allele, currently considered at neutral risk in all populations studied. Objectives: To access the performance of PRS in predicting individuals whilst pre-symptomatic or with mild cognitive impairment who are at greatest risk of progression of cognitive impairment due to Alzheimer’s Disease from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) as measured by the Preclinical Alzheimer Cognitive Composite (PACC) score profile. Design: A longitudinal analysis of data from the ADNI study conducted across over 50 sites in the US and Canada. Setting: Multi-centre genetics study. Participants: 594 subjects either APOE E3 homozygotes or APOE E3/E4 heterozygotes who upon entry to the study were diagnosed as cognitively normal or with mild cognitive impairment. Measurements: Use of genotyping and/or whole genome sequencing data to calculate polygenic risk scores and assess its ability to predict subsequent cognitive decline as measured by PACC over 5 years. Results: Assessing both cognitively normal and mild cognitive impaired subjects using a PRS threshold of greater than 0.6, the high genetic risk participant group declined more than the low risk group over 5 years as measured by PACC score (PACC score reduced by time). Conclusions: Our findings have shown that polygenic risk score provides a promising tool to identify those with higher risk to decline over 5 years regardless of their APOE alleles according to modified PACC profile, especially its ability to identify APOE3/E3 cognitively normal individuals who are at most risk for early cognitive decline. This genotype accounts for approximately 60% of the general population and 35% of the AD population but currently would not be considered at higher risk without access to expensive or invasive biomarker testing.

CITATION:
Q. Gao ; P. Daunt ; A.M. Gibson ; R.J. Pither ; for the Alzheimer’s Disease Neuroimaging Initiative (2022): Utility of Polygenic Risk Scoring to Predict Cognitive Impairment as Measured by Preclinical Alzheimer Cognitive Composite Score. The Journal of Aging and Lifestyle (JARLife). http://dx.doi.org/10.14283/jarlife.2022.1

OPEN ACCESS

Download PDF (593.32 Ko) View HTML

Read more...

CLINICAL RATINGS OF WHITE MATTER HYPERINTENSITIES, HIPPOCAMPAL RATINGS, AND NEUROPSYCHOLOGICAL FUNCTIONING FROM THE CACHE COUNTY MEMORY STUDY

T.J. Farrer, E.D. Bigler, Y.H.W. Tsui-Caldwell, T.J. Abildskov, J.A.T. Tschanz, M.C. Norton, K.A. Welsh-Bohmer

J Aging Res & Lifestyle 2022;11:9-13

Show summaryHide summary

Objective: White matter burden and medial temporal atrophy are associated with cognitive health. A large epidemiological database, such as the Cache County Memory Study (CCMS), can provide additional insight into how visual clinical ratings of brain structural integrity predict cognition in older adults. Method: We used the Scheltens Ratings Scale to quantify white matter lesion burden and medial temporal atrophy in the CCMS sample to determine if these qualitative markers are predictive of memory function. We performed clinical ratings of MRI scans across two ascertainment periods among 187 community-dwelling older adults and correlated these ratings with MMSE, CERAD memory performance, and general cognitive ability. Results: Higher Scheltens ratings measuring white matter and basal ganglia hyperintensities were associated with lower memory performance (r = 0.21). The strongest correlations were observed between medial temporal atrophy and general cognition performance (r = 0.32). Conclusions: The current findings support previous research that the integrity of different regions of the brain correlate to function in a meaningful way.

CITATION:
T.J. Farrer ; E.D. Bigler ; Y.H.W. Tsui-Caldwell ; T.J. Abildskov ; J.A.T. Tschanz ; M.C. Norton ; K.A. Welsh-Bohmer (2022): Clinical Ratings of White Matter Hyperintensities, Hippocampal Ratings, and Neuropsychological Functioning from the Cache County Memory Study. The Journal of Aging and Lifestyle (JARLife). http://dx.doi.org/10.14283/jarlife.2022.2

OPEN ACCESS

Download PDF (220.1 Ko) View HTML

Read more...

SOCIAL WELL-BEING, PSYCHOLOGICAL FACTORS, AND CHRONIC CONDITIONS AMONG OLDER ADULTS

J. Min, Y-C. Yeh, I.S. Harvey

J Aging Res & Lifestyle 2022;11:14-19

Show summaryHide summary

Abstract: Background: Aging is characterized by the decline in physical health, functional status, and loss of social roles and relationships that can challenge the quality of life. Social well-being may help explain how aging individuals experience declining physical health and social relationships. Despite the high prevalence of chronic conditions among older adults, research exploring the relationship between social well-being and chronic disease is sparse. Objectives: The study aims were to investigate the relationship between social well-being and psychological factors (e.g., perceived control, life satisfaction, self-esteem, active coping, optimism, and religious coping) by chronic condition in older adults. Design: Cross-sectional study. Participants: The current study comprises older adults (N = 1,251, aged ≥ 65 y) who participated in the third wave of the National Survey of Midlife in the United States (i.e., MIDUS). Setting: MIDUS was conducted on a random-digit-dial sample of community-dwelling, English-speaking adults. Measurements: Six instruments representing psychological resources (life satisfaction, perceived control, self-esteem, optimism, active coping, and religious coping) and five dimensions of social well-being (social actualization, social coherence, social acceptance, social contribution, social integration) were measured. An index of chronic disease comprised of self-reported data whether they had received a physician’s diagnosis for any chronic conditions over the past year. Results: The findings indicated that the individuals without chronic conditions had significantly higher social integration, social acceptance, and social contribution scores than the individuals with chronic conditions (t = 2.26, p < 0.05, t = 2.85, p < 0.01, and t = 2.23, p < 0.05, respectively). For individuals diagnosed with more than one chronic condition, perceived control, self-esteem, and optimism were positively related to their social well-being (β = .33, p < .001, β = .17, p < .001, and β = .33, p < .001, respectively). Conclusion: Findings suggested that older adults with multiple chronic conditions have a decrease in social well-being. Chronic disease management programs may help increase social well-being among individuals with multiple chronic conditions.

CITATION:
J. Min ; Y-C. Yeh ; I.S. Harvey ; (2022): Social Well-Being, Psychological Factors, and Chronic Conditions among Older Adults. The Journal of Aging and Lifestyle (JARLife). http://dx.doi.org/10.14283/jarlife.2022.3

Download PDF (530.25 Ko) View HTML

Read more...