ANTIOXIDANT EFFECTS OF A NUTRITIONAL SUPPLEMENT CONTAINING POLYPHENOLS AND MICRONUTRIENTS IN POSTMENOPAUSAL WOMEN: A RANDOMIZED CONTROLLED STUDY
N.N. Kang, A.V. Rao, K. De Asis, L.Chan, L.G. Rao
J Aging Res Clin Practice 2012;1(3):183-187
Background: Oxidative stress is an important factor in the development of osteoporosis. Antioxidants counteract the damaging effect of oxidative stress, which may reduce the risk of osteoporosis. Nutritional supplements, such as greens+TM and greens+ bone builderTM that contain water-soluble polyphenols and other micronutrients beneficial for bone health, are of recent interest as complementary strategies in the management of osteoporosis. Objective: Clinically evaluate the antioxidant properties of greens+ bone builderTM in postmenopausal women. Design: Forty-seven postmenopausal women, 50-60 years old were recruited for a ten-week clinical study. During week 1, participants recorded their baseline food intake. During week 2, the participants refrained from consuming polyphenol-rich foods, beverages and supplements. The participants were then randomized to either Treatment group consuming 1 scoop (equivalent to ¼ cup) daily of greens+ bone builderTM (N=23) or Placebo (N=24) group for a period of 8 weeks. Blood samples were collected at 0, 4 and 8 weeks of supplementation, processed and assayed for serum total antioxidant capacity (TAC), lipid peroxidation and protein oxidation as markers of oxidative stress. Results: Statistical analysis showed that after 4 and 8 weeks, the Treatment group significantly increased their serum total antioxidant capacity and decreased in lipid peroxidation and protein oxidation while the Placebo group showed no significant changes. These were also significantly different from those of the Placebo group. Conclusions: Results suggest that a daily supplementation with greens+ bone builderTM may be important in reducing oxidative damage, thus reducing the risk of osteoporosis in postmenopausal women.