UPPER EXTREMITY MUSCLE VOLUME AND FUNCTION AS INDICATORS OF PRE-FRAILTY IN OLDER ADULT PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
E. Miyamoto, M. Kaneko3, , E. Miyamoto, M. Kaneko, S. Ichimaru, Y. Hokotachi, T. Amagai
J Aging Res Clin Practice 2016;5(3):147-154
Background: In a survey of 2004 conducted by World Health Organization, chronic obstructive pulmonary disease (COPD) is proved third leading cause of death worldwide and develops frailty. However, the differences between pre-frailty and non-frailty or frailty are not well studied. Objective: To examine the working hypothesis that there is differences in phenotypes between pre-frailty and non-frailty or frailty in patients with COPD. Design and setting: This study is a cross-sectional study. Participants: Patients with consecutive COPD male patients, whose age is 50 year-old or older, visited COPD outpatient clinic at single institute, between 2011, March and August, were eligible. Measurements: The data categorized into seven domains according to Fried’s phenotypic criteria were collected in all subjects divided into three groups: non-, pre-, and frailty. All data was compared between two of three groups. Results: Pre-frail COPD patients showed declines in upper extremities’ muscle volume and functions assessed by arm muscle area and hand-grip strength (P<0.05) compared with data in non-frailty group. This was different from results of comparison data between pre- and frailty group where lower extremities’ muscle data showed statistically different (p<0.05). Conclusion: Our observation could be interpreted that declines in upper extremities’ muscle volume and function might precede in comparison pre-frailty with non-frailty COPD patients. This might be an early predictor to progressing the severity of COPD in pre-frail COPD patients and might be potential factor to prevent deterioration of frailty and COPD severity.
E. Miyamoto ; M. Kaneko ; S. Ichimaru ; Y. Hokotachi ; T. Amagai (2016): Upper extremity muscle VOLUME AND function as indicatorS of pre-frailty in older adult patients with chronic obstructive pulmonary disease (COPD). The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2016.103