CONSUMPTION OF MANGOSTEEN FRUIT PULP POWDER (MX3) PROVIDES BENEFICIAL EFFECT ON KNEE DISCOMFORT NOT ASSOCIATED WITH INJURY. A DOUBLE BLIND, PLACEBO-CONTROLLED PILOT CLINICAL STUDY
R. Rodriguez, Z. Pietrzkowski, R. Keller, T. Reyes-Izquierdo
J Aging Res Clin Practice 2014;3(2):116-119
Aim: To evaluate the effect of purple Mangosteen fruit pulp powder (MX3) on subjects with knee joint discomfort and reduced joint function. Methods: Subjects with self-reported knee discomfort were randomized and blinded for treatment with either a twice daily dose of 500mg daily dose of MX3 (Group 1), a single daily dose of 500mg MX3 (Group 2) or a once a day daily dose of placebo(Group 3) during a 28 day period. Symptoms of discomfort were evaluated using the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the McGill Pain Questionnaire (MPQ) before the treatment and after 10 and 28 days of treatment. Blood samples were also collected for blood chemistry purposes. Results: Thirty six individuals were recruited for this study. Group 1 contained 2 male and 10 female subjects, average age 55 (SD ±5.2), BMI 27.8 (SD ±3.44). Group 2 contained 4 male and 8 female subjects age 59 (SD ±5.1), with a BMI of 28.6 (SD ± 3.7). Group 3 had 1 male and 11 female participants age 55 (SD ± 9.1) BMI 28.5 (SD ± 3.3). All participants completed the study. Data reported on day 28 for the McGill index showed a reduction of 56% on group 1, 46% on group 2 compared to a 9% in the placebo group (p=0.0004). WOMAC showed a 39% reduction on group 1, a 34% in group 2 and a 16% in placebo (p=0.04). CRP analysis in blood did not show any significant differences. Conclusions: Short-term use of MX3 did not show significant improvement at day 10 when compared to placebo. However, results indicate that long term use of MX3 might reduce knee joint discomfort, as indicated by WOMAC and McGill. Further clinical studies will confirm if a long term treatment with MX3 can improve knee joint function and reduce discomfort on subjects showing symptoms of osteoarthritis.
R. Rodriguez ; Z. Pietrzkowski ; R. Keller ; T. Reyes-Izquierdo (2014): CONSUMPTION OF MANGOSTEEN FRUIT PULP POWDER (MX3) PROVIDES BENEFICIAL EFFECT ON KNEE DISCOMFORT NOT ASSOCIATED WITH INJURY. A DOUBLE BLIND, PLACEBO-CONTROLLED PILOT CLINICAL STUDY. The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2014.21