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T. Reyes-Izquierdo, C. Shu, R. Argumedo, B. Nemzer, Z. Pietrzkowski

J Aging Res Clin Practice 2014;3(1):56-60

Purpose: elevATP™, a supplement containing plant-derived inorganic microelements and apple polyphenols, was previously shown to increase endogenous whole blood ATP levels in healthy human subjects. In this report, we tested the supplement in a larger cohort and assessed the effect of the supplement in muscle. Methods: Twenty healthy, fasted, and resting adult human subjects participated in this acute, placebo-controlled, single-dose crossover clinical study. Oral placebo was administered on the first day of testing followed by a single, 150 mg dose of elevATP™ on the second day. Blood was collected immediately prior to treatment, 60 and 120 minutes after ingestion. Whole blood ATP, plasma ATP, hemoglobin, blood lactate, and blood glucose levels were collected. A muscle biopsy was performed on one resting study subject before, and 60 and 120 minutes after, a single dose of elevATP™. Results: elevATP™ increased whole blood levels of ATP by 40% after 60 minutes (p<0.0001) and by 28% after 120 min (p=0.0009) versus baseline, pre-supplementation levels. ATP plasma levels did not increase after elevATP™ administration under these experimental conditions. Intramuscular ATP levels from biopsy of one patient increased significantly at 60 and 120 minutes after ingestion of elevATP™ and reached higher levels than ATP measured in whole blood. Conclusions: These results indicate that elevATP™ increases intracellular ATP in blood cells, confirming results from a previous study, and suggest that it may increase ATP in muscle tissue. Further clinical testing is needed to confirm tissue- and organ-specific changes in ATP levels following ingestion of elevATP™.

T. Reyes-Izquierdo ; C. Shu ; R. Argumedo ; B. Nemzer ; Z. Pietrzkowski (2014): THE EFFECT OF ELEVATP™ ON WHOLE BLOOD ATP LEVELS: A SINGLE DOSE, CROSSOVER CLINICAL STUDY . The Journal of Aging Research and Clinical Practice (JARCP). http://dx.doi.org/10.14283/jarcp.2014.12

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