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THE EFFECT OF ISOFLAVONES SUPPLEMENTATION ON SEX STEROIDS, LIPIDS AND INFLAMMATION MARKERS IN ELDERLY MEN

A. Garrido, M. Pia De La Maza, Y. Muñoz, L. Valladares

J Aging Res Clin Practice 2013;2(1):104-109

Background/Objective: To analyze the biological impact of soy isoflavones intake over specific cardiovascular risk factors, we investigated whether an oral supplement influenced serum levels of lipoprotein, steroids sex hormones and some inflammatory markers in elderly men. Subject/Methods: Thirty healthy men, aged 65-80 years, were invited to take part in this randomized control study, to receive either 100 mg/day of isoflavones supplement (n=15) or identical placebo capsules (n=15). Blood samples obtained at baseline and after 24 weeks were analyzed for total isoflavones, lipoprotein, triglycerides, fibrinogen, adiponectin, leptin, insulin, estradiol, testosterone, DHEA, DHEAS, sex hormone-binding globulin, plasminogen activator inhibitor-1 (PAI-1), P-selectin, high sensitive C-reactive protein (hsCRP) and platelet thromboxane A2 receptor density. Body weight and blood pressure were also registered at baseline and at the end of the treatment. Changes in variables within and between groups were analyzed through ANOVA for repeated measures. Results: The levels of PAI, hsCRP and p-selectin were decreased significantly (p<0.05) after the treatment period only in the intervention group. All the other studied parameters did not change significantly in either group. Conclusion: During this 24–weeks intervention, soy isoflavone intake modified serum levels of PAI-1, hsCRP and P-selectin in elderly men. Further studies with diverse markers of inflammation are necessary to clarify the specific effect of isoflavones on immune response.

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