PHARMACOLOGICAL, BIOCHEMICAL AND TOXICOLOGICAL EVALUATION OF POTASH ALUM AS ANTI-OBESITY AGENT
Z. Ahmed, I. Kazmi, M. Afzal, M. Pravez, R. Singh, S. Saleem, R. Kaur, F. Anwar
J Aging Res Clin Practice 2013;2(1):32-34
The objective of present study was to evaluate the role of Potash Alum as an anti obesity agent in Wistar rats fed on high fat diet (HFD). Animals were fed on HFD (58% fat) with or without Potash Alum for 24 weeks. Results revealed that oral intake of Potash Alum exhibited significant reduction in body weight, food intake, serum triglycerides (TG), total cholesterol (TC), high density lipoproteins (HDL), alkaline phosphatase (ALP), serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT) whereas simultaneously increased the dry weight of feces, total lipids in feces, in kidneys and liver compared to HFD fed control. Furthermore, a particularly new observation i.e., the enlargement of teeth along with gummosis was noticed with the treatment.